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The development of the insulin radioimmunoassay enabled the description of the incretin effect, namely that glucose administered into the gut potentiated insulin secretion to a greater extent than isoglycemic stimulation of insulin secretion achieved through i.v
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4 Future challenges 4.1 Mechanistic validation across ocular pathologies Despite progress in understanding molecular pathways such as calcium channel modulation and mitochondrial mitophagy, the relative contributions of these mechanisms to specific diseases remain unclear
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